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Table 2 Clinical characteristics of H3K27M and H3WT paediatric thalamic glioma

From: Targeted detection of genetic alterations reveal the prognostic impact of H3K27M and MAPK pathway aberrations in paediatric thalamic glioma

 

Characteristic

Number of patients

  

H3WT

H3K27M

  

48

16

Sex

 

Male

28

6

 

Female

20

10

Outcome

 

Alive

35

0

 

Dead

13

16

Histology

 

Low Grade

37

5

 

High Grade

11

11

Grade

 

Pilocytic

23

0

 

Diffuse

0

2

 

Anaplastic

6

3

 

Glioblastoma

5

6

 

Ganglioglioma

3

0

 

Low Grade, NOS

11

3

 

High Grade, NOS

0

2

Extent of Surgery

 

GTR

11

0

 

STR

19

6

 

Partial Resection

3

2

 

Biopsy

7

5

 

Unknown

8

3

Radiation

 

Treated

29

8

 

Not Treated

16

6

 

Unknown

3

2

Chemotherapy

 

Treated

29

6

 

Not Treated

17

9

 

Unknown

2

1

Age at Diagnosis

 

Median

9.02 years

10.50 year

 

Mean

8.24 ± 3.93 years

10.35 ± 3.23 years

Overall Survival

 

Median

9.12 years

1.02 years

 

Mean

11.10 ± 8.69 years

1.81 ± 3.25 years