| All | Group Aa | Group Ba | Group Ca | Group Da | p-valueb |
---|---|---|---|---|---|---|
Total | 758 | 155 | 131 | 237 | 235 | Â |
Mean Age at diagnosis(year) | 53.7 | 44.7 | 41.7 | 56.7 | 63.4 | <0.0001 |
Sex M/F | 426/332 | 90/65 | 75/56 | 134/103 | 127/108 | 0.87 |
Surgery n (%) | ||||||
 Biopsy only | 121 (16) | 16 (10) | 19 (15) | 49 (21) | 37 (16) | 0.05 |
KPS n (%) | ||||||
 100 | 160 (21) | 66 (43) | 51 (40) | 26 (11) | 17 (7) | <0.0001 |
 90 | 268 (35) | 63 (41) | 58 (45) | 83 (35) | 64 (27) | |
 80 | 126 (17) | 13 (8) | 7 (5) | 43 (18) | 63 (27) | |
 70 | 94 (12) | 6 (4) | 8 (6) | 38 (16) | 42 (18) | |
  − 60 | 107 (14) | 7 (5) | 4 (3) | 47 (20) | 49 (21) | |
Adjuvant therapy n (%) | ||||||
 CRT | 559/748 (75) | 83/150 (55) | 70/131 (53) | 201/235 (86) | 205/232 (88) | <0.0001 |
 Chemo only | 58/748 (8) | 32/150 (21) | 5/131 (4) | 7/235 (3) | 14/232 (6) | |
 RT only | 43/748 (6) | 4/150 (3) | 16/131 (12) | 13/235 (6) | 10/232 (4) | |
 None | 88/748 (12) | 31/150 (21) | 40/131 (31) | 14/235 (6) | 3/232 (1) | |
Location n(%) | ||||||
 Cerebrum (with frontal involvement) | 370/756 (49) | 119/154 (77) | 82/131 (63) | 86/237 (36) | 83/234 (35) | <0.0001 |
 Cerebrum (other) | 348/756 (47) | 34/154 (23) | 48/131 (37) | 122/237(53) | 144/234 (63) | |
 Thalamus | 25/756 (3) | 1/154 (0.7) | 0/131 (0) | 18/237 (8) | 6/234 (3) | |
 Infratentorium | 13/756 (2) | 0/154 (0) | 1/131 (0.8) | 11/237 (5) | 1/234 (0.4) | |
Histology n (%) | ||||||
 DA | 63 (8) | 12 (8) | 26 (20) | 19 (8) | 6 (3) | <0.0001 |
 AA | 106 (14) | 7 (5) | 33 (25) | 38 (16) | 28 (12) | |
 GBM | 337 (44) | 9 (6) | 7 (5) | 136 (57) | 185 (79) | |
 OA | 67 (9) | 30 (19) | 28 (21) | 6 (3) | 3 (1) | |
 AOA | 103 (14) | 32 (21) | 29 (22) | 29 (12) | 13 (6) | |
 OL | 47 (6) | 39 (25) | 6 (5) | 2 (1) | 0 (0) | |
 AO | 35 (5) | 26 (17) | 2 (2) | 7 (3) | 0 (0) | |
Molecular background n(%) | ||||||
 Total 1p/19q loss | 148/757 (20) | 144/155 (93) | 4/131 (3) | 0/237 (0) | 0/234 (0) | <0.0001 |
  MGMT methylation | 386/755 (51) | 143/155 (92) | 88/129 (68) | 72/236 (31) | 83/235 (35) | <0.0001 |
  H3.3/H3.1 mutation | 23/510 (5) | 1/31 (3) | 0/21 (0) | 21/233 (9) | 1/235 (0.4) | 0.0001 |
  BRAF V600E | 12/506 (2) | 0/31 (0) | 0/21 (0) | 9/233 (4) | 3/221 (1) | 0.21 |
CDKN2A | ||||||
 Homozygous Del | 116/505 (23) | 4/89 (4) | 7/86 (8) | 37/163 (23) | 68/167 (41) | <0.0001 |
 Heterozygous Del | 72/505 (14) | 5/89 (6) | 6/86 (7) | 22/163 (13) | 39/167 (23) |  |