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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia

Fig. 5

Ultra high-field diffusion tensor imaging reveals preserved structural integrity of major white matter tracts in GFAP-IkBα-dn mice. a Anaesthetised wildtype or GFAP-IkBα-dn mice, either sham-treated or subjected to BCAS, were imaged using ultra high-field DTI MRI. Major white matter tracts (CC, corpus callosum; IC, internal capsule; EC, external capsule) were identified in direction-encoded colour (DEC) images (red, medial to lateral orientation; blue, dorsal to ventral orientation; green, rostral to caudal orientation) based on the primary eigenvectors. b Fractional anisotropy was significantly decreased in all regions of interest in wildtype but not in GFAP-IkBα-dn mice subjected to BCAS. c BCAS induced significant changes in the apparent diffusion coefficient (ADC) of the internal capsule and external capsule in wildtype but not in GFAP-IkBα-dn mice. d-e Axial and radial diffusivity were also significantly altered in wildtype but not in GFAP-IkBα-dn mice subjected to BCAS (wildtype sham, n = 6; wildtype BCAS, n = 5; GFAP-IkBα-dn sham, n = 3; GFAP-IkBα-dn BCAS, n = 5; Mann–Whitney test for all comparisons)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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