Fig. 7
From: LRP1 expression in microglia is protective during CNS autoimmunity
LRP1 is an inhibitor of NF-kB through the MyD88 pathway. a Macrophages isolated from Cx3cr1 cre-Lrp1 fl/fl (LRP1-) and Lrp1 fl/fl (LRP1+) mice were treated with LPS (1 μg/ml) and the expression of p-p65, p65, LRP1 and actin were determined by immunoblot. Representative of 3 independent experiments). b LRP1+ and LRP1- macrophages were treated with TLR ligands and expression of IL-6 was determined by qPCR analysis. *p < 0.05; Student’s t-test, mean ± s.e.m