Fig. 6

LRP1 deficient myeloid cells have a pro-inflammatory signature. Microglia (MG) and BMDM (MΦ) isolated from Cx3cr1 ^cre-Lrp1 ^fl/fl and Lrp1 ^fl/fl mice were treated with LPS (1 μg/mL) for 3 h (qPCR) or 24 h (ELISA). TNF-α expression in microglia was determined by qPCR (a) and ELISA (b). TNF-α expression in macrophages was determined by qPCR (c) and ELISA (d). Expression of IL-1β (e) and IL-6 (f) in macrophages was determined by qPCR. g Transcript expression of IL-1β, IL-6, and TNF-α from the CNS of Cx3cr1 ^creER-Lrp1 ^fl/fl and Lrp1 ^fl/fl mice at the peak of EAE. 5, **p < 0.01, ***p < 0.001; Student’s t-test