Fig. 2

Deletion of LRP1 from microglia, but not from peripheral myeloid cells, exacerbates EAE progression. a LRP1 expression was determined by flow cytometry on microglia and BMDM isolated from LysM ^cre-Lrp1 ^fl/fl and Lrp1 ^fl/fl mice. b Clinical scores and c incidence of LysM ^cre-Lrp1 ^fl/fl and Lrp1 ^fl/fl mice (n = 7–9 for each group, representative of 3 independent experiments). d LRP1 expression was determined by flow cytometry on microglia and BMDM isolated from Cx3cr1 ^creER-Lrp1 ^fl/fl and Lrp1 ^fl/fl mice. e Clinical scores and f incidence of Cx3cr1 ^creER-Lrp1 ^fl/fl and Lrp1 ^fl/fl mice (n = 6–10 for each group, representative of 3 independent experiments.). 2-way ANOVA was used for the mean clinical score and the log-rank (Mantle-Cox) test was used for incidence. ***p < 0.001, mean ± s.e.m