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Table 1 Demographic, genetic, and biomarker data summarized by diagnostic group

From: The relationship between complement factor C3, APOE ε4, amyloid and tau in Alzheimer’s disease

 

NC

MCI

AD

 

N

71

110

56

P-value

Age (Mean ± SE)

76.5 ± 0.7

75.6 ± 0.7

74.9 ± 1.0

0.19

Sex (M/F)

36/35

72/38

30/26

0.11

CDR-SB (Mean ± SE)

0.04 ± 0.02

1.55 ± 0.09

4.13 ± 0.20

<0.001

APOE ε4 Dose (0/1/2)

56/14/1

47/49/14

17/25/14

<0.001

CSF amyloid β1-42 (Mean ± SE)

209.2 ± 6.2

158.6 ± 4.7

139.3 ± 4.4

<0.001

CSF ptau181p (Mean ± SE)

25.5 ± 1.7

36.2 ± 1.5

43.0 ± 2.6

<0.001

CSF C3 (Mean ± SE)

−2.56 ± 0.02

−2.57 ± 0.02

−2.58 ± 0.02

0.53

  1. SE standard error, M male, F female, CDR-SB clinical dementia rating sum of boxes score, MMSE mini mental state exam, NC normal control, MCI mild cognitive impairment, AD Alzheimer’s Disease