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Table 1 Demographic, genetic, and biomarker data summarized by diagnostic group

From: The relationship between complement factor C3, APOE ε4, amyloid and tau in Alzheimer’s disease

  NC MCI AD  
N 71 110 56 P-value
Age (Mean ± SE) 76.5 ± 0.7 75.6 ± 0.7 74.9 ± 1.0 0.19
Sex (M/F) 36/35 72/38 30/26 0.11
CDR-SB (Mean ± SE) 0.04 ± 0.02 1.55 ± 0.09 4.13 ± 0.20 <0.001
APOE ε4 Dose (0/1/2) 56/14/1 47/49/14 17/25/14 <0.001
CSF amyloid β1-42 (Mean ± SE) 209.2 ± 6.2 158.6 ± 4.7 139.3 ± 4.4 <0.001
CSF ptau181p (Mean ± SE) 25.5 ± 1.7 36.2 ± 1.5 43.0 ± 2.6 <0.001
CSF C3 (Mean ± SE) −2.56 ± 0.02 −2.57 ± 0.02 −2.58 ± 0.02 0.53
  1. SE standard error, M male, F female, CDR-SB clinical dementia rating sum of boxes score, MMSE mini mental state exam, NC normal control, MCI mild cognitive impairment, AD Alzheimer’s Disease