Fig. 4
From: The relationship between complement factor C3, APOE ε4, amyloid and tau in Alzheimer’s disease
Proposed biological model for the relationships between C3, APOE ε4, and amyloid on ptau. A proposed model for the relationships between C3, APOE ε4, and amyloid on ptau based on results from our statistical analyses. Solid arrows represent main effects of each variable and dotted arrows represent the interaction effect of two variables, all assessed in multivariate linear models which included age, sex, and CDR-SB score as covariates. Roman numerals represent the following effects: (I) interaction effect of C3 and APOE ε4 on amyloid (II) interaction effect of C3 and APOE ε4 on ptau, and (III) the effect of C3 on ptau, which is mediated by amyloid