Fig. 4
From: Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes
High resolution imaging of aggregates in AxD astrocytes with 3D-SIM or electron microscopy. a Super resolution imaging of GFAP aggregates with dot-like pattern showed accumulated particles of both GFAP and alpha-B crystalline (CRYAB). Scale bar = 200 nm. b Electron microscopy of AxD astrocytes. Electron-dense amorphous-appearing structures (open arrow head) or granular (closed arrow head) structures, surrounded by filamentous structure (*). Scale bars = 100 nm