Fig. 1
From: Modeling Alexander disease with patient iPSCs reveals cellular and molecular pathology of astrocytes
Generation of iPSCs from Alexander disease patients and healthy controls. a Morphology and expression of human embryonic stem cell markers. iPSCs from both controls and patients with Alexander disease showed ESC-like morphology (phase image) and expressed pluripotent stem cell markers, NANOG and TRA1-60. Scale bars = 200 μm. b In vitro differentiation of established iPSCs to representative three-germ layer: TUJ1 (ectoderm), αSMA (mesoderm), and SOX17 (endoderm). Scale bars = 50 μm