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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Heterogeneity of cerebral TDP-43 pathology in sporadic amyotrophic lateral sclerosis: Evidence for clinico-pathologic subtypes

Fig. 5

pTDP-43 immunoblot analysis. Immunoblot analysis of sarkosyl-insoluble fractions from the affected cortex of FTLD-TDP Type A, B, and C cases (two each; upper panels), and Type 1, Type 2a and Type 2b cases (four each; lower panels) immunostained with anti- phosphorylated TDP-43 antibody (pTDP-43, phospho Ser409/410). In all cases from the three ALS groups, both the upper (24-kDa) and lower (23-kDa) bands of the C-terminal fragments of pTDP-43 are clearly detected, and the pattern of these fragments is similar to those shown in FTLD-TDP Type B, and not in FTLD-TDP Type A or Type C

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Acta Neuropathologica Communications

ISSN: 2051-5960

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