Table 2 GABAergic Interneurone Markers and Glutamatergic Markers in the Primary Visual Cortex in Dementia with Lewy Bodies and Alzheimer’s disease

GAD1 mRNA

1.46 ± 0.62

0.86 ± 0.22

0.62 ± 0.15*

GAD67 protein

0.85 ± 0.21

0.85 ± 0.16

0.72 ± 0.13

GAD65 protein

1.12 ± 0.26

1.16 ± 0.26

0.91 ± 0.15

PVALB mRNA

1.59 ± 0.47

0.87 ± 0.24†

3.51 ± 0.55**

PVALB protein

0.70 ± 0.22

0.61 ± 0.25*

0.87 ± 0.25***

NPY pg/mg

5.71 ± 1.95

6.63 ± 1.62

7.39 ± 1.52*

SST ng/mg

0.42 ± 0.18

0.48 ± 0.15

0.60 ± 0.27†

GABARAP-17 kDa

1.56 ± 0.28

0.91 ± 0.19***

1.29 ± 0.28**

GABARAP-14 kDa

1.47 ± 0.27

0.99 ± 0.14***

1.15 ± 0.26**

Gephyrin

1.13 ± 0.27

0.84 ± 0.08**

0.67 ± 0.09**

GABA A α1

0.75 ± 0.30

0.82 ± 0.26

0.83 ± 0.39

Kif5A

0.95 ± 0.58

0.51 ± 0.10†

0.90 ± 0.09

GRIN2A mRNA

1.44 ± 0.79

0.70 ± 0.16

0.89 ± 0.31

GluR1/GRIA1 protein

0.94 ± 0.13

0.89 ± 0.33

NT

vGlut1(SLC17A7) protein 61.3 kDa

1.20 ± 0.24

1.04 ± 0.18

0.91 ± 0.11†

vGlut1(SLC17A7) protein 59.3 kDa

0.90 ± 0.13

0.87 ± 0.1

0.90 ± 0.12

PSD95 (DLG4) mRNA

3.33 ± 1.14

1.80 ± 0.61†

0.83 ± 0.26*

PSD-95 protein

1.25 ± 0.22

0.62 ± 0.19***

1.24 ± 0.28

GAP43 protein

1.25 ± 0.45

0.71 ± 0.22***

1.08 ± 0.16

BDNF mRNA

0.70 ± 0.16

0.39 ± 0.14*

0.71 ± 0.48

BDNF protein

ND

ND

ND

Synaptophysin (SYP) mRNA

1.76 ± 0.72

0.89 ± 0.22

2.69 ± 0.80

Synaptophysin protein

0.96 ± 0.25

0.54 ± 0.09***

0.72 0.16*

SNAP25 mRNA

1.27 ± 0.30

0.88 ± 0.23

0.83 ± 0.25

SNAP25 protein

1.10 ± 0.28

0.99 ± 0.13

1.10 ± 0.17