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Table 1 Microarray analysis of Gene Expression in Primary Visual Cortex in DLB

From: Analysis of primary visual cortex in dementia with Lewy bodies indicates GABAergic involvement associated with recurrent complex visual hallucinations

symbol name logFC adj.P.Val
PENK proenkephalin 2.328 0.003
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 2.029 0.001
SOWAHA sosondowah ankyrin repeat domain family member A 1.588 0.001
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 1.583 0.001
TAC1 tachykinin, precursor 1.537 0.003
FKBP1A FK506 binding protein 1A, 12 kDa 1.527 0.001
PRKCB protein kinase C, beta 1.489 0.003
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 1.452 0.022
ELMOD1 ELMO/CED-12 domain containing 1 1.436 0.001
RTN4 reticulon 4 1.409 0.001
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 1.388 0.003
GPR6 G protein-coupled receptor 6 1.387 0.003
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 1.372 0.002
COCH cochlin 1.355 0.005
CRYM crystallin, mu 1.334 0.035
SLC32A1 solute carrier family 32 (GABA transporter), member 1 1.329 0.010
PRKCB protein kinase C, beta 1.318 0.006
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 1.297 0.001
GUCY1A3 guanylate cyclase 1, soluble, alpha 3 1.285 0.004
FGF13 fibroblast growth factor 13 1.265 0.001
SYT1 synaptotagmin I 1.243 0.009
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 1.236 0.020
CT45A1 cancer/testis antigen family 45, member A1 1.230 0.047
LPL lipoprotein lipase 1.226 0.007
MAP7D2 MAP7 domain containing 2 1.199 0.004
PDYN prodynorphin 1.196 0.046
TSPAN13 tetraspanin 13 1.182 0.003
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 1.180 0.003
TUSC3 tumor suppressor candidate 3 1.164 0.001
NELL2 NEL-like 2 (chicken) 1.161 0.010
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 1.153 0.001
SYN2 synapsin II 1.151 0.009
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 1.150 0.003
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 1.147 0.001
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 1.139 0.003
GAD2 glutamate decarboxylase 2 (65 kDa) 1.132 0.014
PPP4R4 protein phosphatase 4, regulatory subunit 4 1.125 0.002
ANKRD34B ankyrin repeat domain 34B 1.123 0.003
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 1.117 0.005
NSF N-ethylmaleimide-sensitive factor 1.112 0.002
BTBD10 BTB (POZ) domain containing 10 1.105 0.001
SCN2B sodium channel, voltage-gated, type II, beta subunit 1.099 0.003
NSF N-ethylmaleimide-sensitive factor 1.087 0.002
RTN1 reticulon 1 1.083 0.005
PARM1 prostate androgen-regulated mucin-like protein 1 1.078 0.010
ANO3 anoctamin 3 1.076 0.029
CRYM crystallin, mu 1.072 0.030
CNR1 cannabinoid receptor 1 (brain) 1.072 0.039
LPPR4 lipid phosphate phosphatase-related protein type 4 1.069 0.001
MAP2K1 mitogen-activated protein kinase kinase 1 1.065 0.001
AKAP11 A kinase (PRKA) anchor protein 11 1.054 0.001
INPP5A inositol polyphosphate-5-phosphatase, 40 kDa 1.043 0.027
PAM peptidylglycine alpha-amidating monooxygenase 1.041 0.006
ERICH3 glutamate-rich 3 1.041 0.003
HPRT1 hypoxanthine phosphoribosyltransferase 1 1.030 0.001
ABHD12B abhydrolase domain containing 12B 1.025 0.002
NBEA neurobeachin 1.024 0.002
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 1.021 0.001
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 1.011 0.001
DCLK1 doublecortin-like kinase 1 1.010 0.018
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 1.000 0.002
SLC14A1 solute carrier family 14 (urea transporter), member 1 −1.020 0.033
IL4R interleukin 4 receptor −1.071 0.039
GSTM1 glutathione S-transferase mu 1 −1.090 0.025
SQSTM1 sequestosome 1 −1.098 0.044
VWF von Willebrand factor −1.101 0.039
NPIPB4 nuclear pore complex interacting protein family, member B4 −1.141 0.004
TAGLN transgelin −1.178 0.004
LOC285407 asparagine-linked glycosylation 1 homolog pseudogene −1.184 0.001
TMEM137 TMEM137 −1.244 0.002
HBA2 hemoglobin, alpha 2 −1.382 0.043
TXNIP thioredoxin interacting protein −1.522 0.003
  1. Listing of significantly altered genes (±2.0 fold change, FDR < 0.05) from the whole genome microarray are displayed along with their average fold change. Neuropeptide/GABAergic interneurone markers are highlighted in bold