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Table 1 Microarray analysis of Gene Expression in Primary Visual Cortex in DLB

From: Analysis of primary visual cortex in dementia with Lewy bodies indicates GABAergic involvement associated with recurrent complex visual hallucinations

symbol

name

logFC

adj.P.Val

PENK

proenkephalin

2.328

0.003

HTR2C

5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled

2.029

0.001

SOWAHA

sosondowah ankyrin repeat domain family member A

1.588

0.001

MAL2

mal, T-cell differentiation protein 2 (gene/pseudogene)

1.583

0.001

TAC1

tachykinin, precursor

1.537

0.003

FKBP1A

FK506 binding protein 1A, 12 kDa

1.527

0.001

PRKCB

protein kinase C, beta

1.489

0.003

ENTPD3

ectonucleoside triphosphate diphosphohydrolase 3

1.452

0.022

ELMOD1

ELMO/CED-12 domain containing 1

1.436

0.001

RTN4

reticulon 4

1.409

0.001

ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

1.388

0.003

GPR6

G protein-coupled receptor 6

1.387

0.003

PPP3CA

protein phosphatase 3, catalytic subunit, alpha isozyme

1.372

0.002

COCH

cochlin

1.355

0.005

CRYM

crystallin, mu

1.334

0.035

SLC32A1

solute carrier family 32 (GABA transporter), member 1

1.329

0.010

PRKCB

protein kinase C, beta

1.318

0.006

AP1S1

adaptor-related protein complex 1, sigma 1 subunit

1.297

0.001

GUCY1A3

guanylate cyclase 1, soluble, alpha 3

1.285

0.004

FGF13

fibroblast growth factor 13

1.265

0.001

SYT1

synaptotagmin I

1.243

0.009

GABRA5

gamma-aminobutyric acid (GABA) A receptor, alpha 5

1.236

0.020

CT45A1

cancer/testis antigen family 45, member A1

1.230

0.047

LPL

lipoprotein lipase

1.226

0.007

MAP7D2

MAP7 domain containing 2

1.199

0.004

PDYN

prodynorphin

1.196

0.046

TSPAN13

tetraspanin 13

1.182

0.003

PDP1

pyruvate dehyrogenase phosphatase catalytic subunit 1

1.180

0.003

TUSC3

tumor suppressor candidate 3

1.164

0.001

NELL2

NEL-like 2 (chicken)

1.161

0.010

SSX2IP

synovial sarcoma, X breakpoint 2 interacting protein

1.153

0.001

SYN2

synapsin II

1.151

0.009

ITPR1

inositol 1,4,5-trisphosphate receptor, type 1

1.150

0.003

AP1S1

adaptor-related protein complex 1, sigma 1 subunit

1.147

0.001

AP1S1

adaptor-related protein complex 1, sigma 1 subunit

1.139

0.003

GAD2

glutamate decarboxylase 2 (65 kDa)

1.132

0.014

PPP4R4

protein phosphatase 4, regulatory subunit 4

1.125

0.002

ANKRD34B

ankyrin repeat domain 34B

1.123

0.003

ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

1.117

0.005

NSF

N-ethylmaleimide-sensitive factor

1.112

0.002

BTBD10

BTB (POZ) domain containing 10

1.105

0.001

SCN2B

sodium channel, voltage-gated, type II, beta subunit

1.099

0.003

NSF

N-ethylmaleimide-sensitive factor

1.087

0.002

RTN1

reticulon 1

1.083

0.005

PARM1

prostate androgen-regulated mucin-like protein 1

1.078

0.010

ANO3

anoctamin 3

1.076

0.029

CRYM

crystallin, mu

1.072

0.030

CNR1

cannabinoid receptor 1 (brain)

1.072

0.039

LPPR4

lipid phosphate phosphatase-related protein type 4

1.069

0.001

MAP2K1

mitogen-activated protein kinase kinase 1

1.065

0.001

AKAP11

A kinase (PRKA) anchor protein 11

1.054

0.001

INPP5A

inositol polyphosphate-5-phosphatase, 40 kDa

1.043

0.027

PAM

peptidylglycine alpha-amidating monooxygenase

1.041

0.006

ERICH3

glutamate-rich 3

1.041

0.003

HPRT1

hypoxanthine phosphoribosyltransferase 1

1.030

0.001

ABHD12B

abhydrolase domain containing 12B

1.025

0.002

NBEA

neurobeachin

1.024

0.002

HS6ST2

heparan sulfate 6-O-sulfotransferase 2

1.021

0.001

DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

1.011

0.001

DCLK1

doublecortin-like kinase 1

1.010

0.018

DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

1.000

0.002

SLC14A1

solute carrier family 14 (urea transporter), member 1

−1.020

0.033

IL4R

interleukin 4 receptor

−1.071

0.039

GSTM1

glutathione S-transferase mu 1

−1.090

0.025

SQSTM1

sequestosome 1

−1.098

0.044

VWF

von Willebrand factor

−1.101

0.039

NPIPB4

nuclear pore complex interacting protein family, member B4

−1.141

0.004

TAGLN

transgelin

−1.178

0.004

LOC285407

asparagine-linked glycosylation 1 homolog pseudogene

−1.184

0.001

TMEM137

TMEM137

−1.244

0.002

HBA2

hemoglobin, alpha 2

−1.382

0.043

TXNIP

thioredoxin interacting protein

−1.522

0.003

  1. Listing of significantly altered genes (±2.0 fold change, FDR < 0.05) from the whole genome microarray are displayed along with their average fold change. Neuropeptide/GABAergic interneurone markers are highlighted in bold
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Acta Neuropathologica Communications

ISSN: 2051-5960

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