Fig. 8

Notch1 signaling in AD patients. a) Immunohistochemistry using an antibody specific for NICD1 shows that in AD cortices the activation of Notch1 in pyramidal neurons is lower as compared to the healthy controls (inserts). b–c) Box plots summarizing the NICD signal shows a significant difference in immunoreactivity in (b) hippocampal and (c) cortical neurons between AD and healthy CTLs. d) Bar graph showing the fold change in transcript levels of Notch1 and some target genes, such as Hes1, Hey1 and BDNF. Only the mRNA of Notch1 is near to significance (0 = p=0.06). Error bars are SEM. Scale bar in (a) is 50 μm