Fig. 5

Notch1 colocalizes with p-Tau in fibrillary plaques. a–a’) In the entorhinal cortex of demented patients, Notch1 costaining with p-Tau surrounds Thioflavin T labeled plaques (arrows in a’), whereas in the healthy control (a) there is no presence of aberrant aggregates. b–b’) In the AD cortical tissue, Notch1 is co-expressed with p-Tau in NF-200 positive neurofibrillary filaments (arrows in b’), whereas there is no apparent colocalization in the healthy control tissue (b). c–d) Bar graphs indicating the amount of plaques either in the hippocampus (c) or in the entorhinal cortex (d) positive for Notch1, p-Tau and double stained. *= p<0.05, **= p<0.01, ***= p<0.001. Error bars are SEM. In all panels scale bars are 40 μm