Fig. 6

Fasudil treatment improves recognition memory of α-Syn^A53T mice. a α-Syn^A53T mice were treated with Fasudil at 10 mg/kg bw and 30 mg/kg bw starting at day 50 (DOB = day of birth). Novel object recognition test (NOR) was performed after 200 days, and after the mouse showed clinical symptoms of the disease by impaired rotarod performance. b Mice were videotaped in an arena with a familiar (F) and a novel (N) object. The time each mouse was heading the objects in the respective zone of interaction (ZOI) was recorded. General activity was tracked simultaneously. c, d The discrimination ratio (c) and distance moved (d) are displayed for the respective treatment groups as compared to controls after disease onset (n(wt ctrl) = 7, n(A53T ctrl) = 8, n(A53T Fas10) = 10, n(A53T Fas30) = 9). Data are displayed as means ± SEM; *p < 0.05, **p < 0.01; T-Test for comparisons between ctrl groups; ANOVA with Dunnett post-hoc test for multiple group comparisons between α-Syn^A53T groups