Skip to main content

Table 2 Univariate- and multivariate Cox proportional hazard regression models of analyzed factors and clinical co-factors. Significant P-values are written in italics

From: TP53 hotspot mutations are predictive of survival in primary central nervous system lymphoma patients treated with combination chemotherapy

Survival outcome Univariate survival analysis Multivariate survival analysis
Factor Cox proportional hazard model Cox proportional hazard model
Co-factors P-value (Hazard ratio, [95 % confidence intervals]) P-value (Hazard ratio, [95 % confidence intervals])
Progression free survival   
Hot Spot/Direct DNA Contact MUT-TP53 0.0046 (1.97, [1.14-3.01]) 0.0083 (1.95, [1.19–3.21])
 Age   0.94 (1.0, [0.96–1.05])
 Sex   
  Female   1.00 (1.00, [1.00–1.00])
  Male   0.18 (0.63, [0.32–1.25])
 IPI   
  Low   1.00 (1.00, [1.00–1.00])
  High   0.36 (1.45, [0.65–3.24])
Overall survival   
Hot Spot/Direct DNA Contact MUT-TP53 0.028 (1.67, [1.06–2.67]) 0.012 (1.86, [1.14–3.01])
 Age   0.20 (1.03, [0.98–1.08])
 Sex   
  Female   1.00 (1.00, [1.00–1.00])
  Male   0.35 (0.71, [0.34–1.46])
 IPI   
  Low   1.00 (1.00, [1.00–1.00])
  High   0.42 (1.44, [0.59–3.48])
Progression free survival   
Double Hit, MUT-TP53 and MIR34A-meth 0.010 (2.96, [1.29–6.76]) 0.066 (2.30, [0.95–5.57])
 Age   0.73 (0.99, [0.95–1.04])
 Sex   
  Female   1.00 (1.00, [1.00–1.00])
  Male   0.07 (0.50, [0.24–1.06])
 IPI   
  Low   1.00 (1.00, [1.00–1.00])
  High   0.26 (1.69, [0.68–4.19])