Table 2 Univariate- and multivariate Cox proportional hazard regression models of analyzed factors and clinical co-factors. Significant P-values are written in italics
Survival outcome | Univariate survival analysis | Multivariate survival analysis |
|---|---|---|
Factor | Cox proportional hazard model | Cox proportional hazard model |
Co-factors | P-value (Hazard ratio, [95 % confidence intervals]) | P-value (Hazard ratio, [95 % confidence intervals]) |
Progression free survival | ||
Hot Spot/Direct DNA Contact MUT-TP53 | 0.0046 (1.97, [1.14-3.01]) | 0.0083 (1.95, [1.19–3.21]) |
Age | 0.94 (1.0, [0.96–1.05]) | |
Sex | ||
Female | 1.00 (1.00, [1.00–1.00]) | |
Male | 0.18 (0.63, [0.32–1.25]) | |
IPI | ||
Low | 1.00 (1.00, [1.00–1.00]) | |
High | 0.36 (1.45, [0.65–3.24]) | |
Overall survival | ||
Hot Spot/Direct DNA Contact MUT-TP53 | 0.028 (1.67, [1.06–2.67]) | 0.012 (1.86, [1.14–3.01]) |
Age | 0.20 (1.03, [0.98–1.08]) | |
Sex | ||
Female | 1.00 (1.00, [1.00–1.00]) | |
Male | 0.35 (0.71, [0.34–1.46]) | |
IPI | ||
Low | 1.00 (1.00, [1.00–1.00]) | |
High | 0.42 (1.44, [0.59–3.48]) | |
Progression free survival | ||
Double Hit, MUT-TP53 and MIR34A-meth | 0.010 (2.96, [1.29–6.76]) | 0.066 (2.30, [0.95–5.57]) |
Age | 0.73 (0.99, [0.95–1.04]) | |
Sex | ||
Female | 1.00 (1.00, [1.00–1.00]) | |
Male | 0.07 (0.50, [0.24–1.06]) | |
IPI | ||
Low | 1.00 (1.00, [1.00–1.00]) | |
High | 0.26 (1.69, [0.68–4.19]) |