TP53 hotspot mutations are predictive of survival in primary central nervous system lymphoma patients treated with combination chemotherapy

Munch-Petersen, Helga D.; Asmar, Fazila; Dimopoulos, Konstantinos; Areškevičiūtė, Aušrinė; Brown, Peter; Girkov, Mia Seremet; Pedersen, Anja; Sjö, Lene D.; Heegaard, Steffen; Broholm, Helle; Kristensen, Lasse S.; Ralfkiaer, Elisabeth; Grønbæk, Kirsten

doi:10.1186/s40478-016-0307-6

Table 1 Structural classification of TP53 mutations in primary central nervous system lymphoma. The structural classification includes an absolute number of 39 TP53 mutations divided on 32 patients, of which 24 combination chemotherapy treated patients harbored 28 mutations (IDs 1–24), and the remaining 8, who harbored 11 mutations, received other therapies (IDs 25–32)

From: TP53 hotspot mutations are predictive of survival in primary central nervous system lymphoma patients treated with combination chemotherapy

ID	Exon	TP53 Mutation	Sequence change	Protein change	Basepair change	Localization	Hotspot mutation	Direct DNA contact/Zn	CpG Site	Conserved region	Siftclass	Mutation type	Transactivation class
1	5I	CYS-135-TYR	TGC > TAC	p.C135Y	C.404G > A	LSH				2	Deleterious	Missense	Non-Active
2	5I	THR-140-ILE	ACC > ATC	p.T140I	C.419C > T	β				2	Deleterious	Missense	Partially Active
3	5I	PRO-142-SER	CCT > TCT	p.P142S	C.424C > T	β				2	Deleterious	Missense	Partially Active
4a	5I	GLN-144-STOP	CAG > CTG	p.Q144	C.430C > T	β				99	Deleterious	Nonsense	NA
5a	5I	ASP-148-ASN	GAT > AAT	p.D148N	C.442G > A	L2				3	Neutral	Missense	Active
6	5II	MET-169-ILE	ATG > ATA	p.M169I	C.507G > A	L2				3	Partially Deleterious	Missense	Partially Active
7	5II	MET-169-ILE	ATG > ATA	p.M169I	C.507G > A	L2				3	Partially Deleterious	Missense	Partially Active
8	5II	MET-169-ILE	ATG > ATA	p.M169I	C.507G > A	L2				3	Partially Deleterious	Missense	Partially Active
9	5II	GLU-171-LYS	GAG > AAG	p.E171K	C.511G > A	L2				3	Deleterious	Missense	Active
10a	5II	VAL-173-MET	GTG > ATG	p.V173M	C.517G > A	L2				3	Deleterious	Missense	Non-Active
10b	5II	ARG-181-HIS	CGC > CAC	p.R181H	c.542G > A	L2			CpG	3	Deleterious	Missense	Partially Active
11	5II	ARG-175-HIS	CGC > CAC	p.R175H	C.524G > A	L2	Hotspot	Direct DNA Contact	CpG	3	Deleterious	Missense	Non-Active
12	5II	ARG-175-HIS	CGC > CAC	p.R175H	C.524G > A	L2	Hotspot	Direct DNA Contact	CpG	3	Deleterious	Missense	Non-Active
5b	5II	Frameshift	deletion	NA	C.528.del1	L2		Zn-binding Site	CpG	3	Frameshift	Deletion	NA (Zn-binding Site)
13	5II	HIS-179-ARG	CAT > CGT	p.H179R	C.536A > G	L2	Hotspot	Zn-binding Site		3	Deleterious	Missense	Non-Active
14	5II	ASP-184-GLY	GAT > GGT	p.D184G	C.551A > G	L2				3	Neutral	Missense	Active
15	6	ARG-202-CYS	CGT > TGT	p.R202C	C.604C > T	β			CpG	99	Deleterious	Missense	Active
16a	6	ASP-208-GLY	GAC > GGC	p.D208G	C.623A > G	β				99	Deleterious	Missense	Active
17	7	TYR-236-CYS	TAC > TGC	p.Y236C	C.707A > G	β				99	Deleterious	Missense	Non-Active
4b	7	MET-237-VAL	ATG > GTG	p.M237V	C.709A > G	L3				99	Deleterious	Missense	Non-Active
18	7	ASN-239-SER	AAC > AGC	p.N239S	C.716A > G	L3	Hotspot	Direct DNA Contact		4	Deleterious	Missense	Non-Active
19	7	ARG-248-GLN	CGG > CAG	p.R248Q	C.743G > A	L3	Hotspot	Direct DNA Contact	CpG	4	Deleterious	Missense	Non-Active
20	7	ARG-249-LYS	AGG > AAG	p.R249K	C.746G > A	L3	Hotspot	Direct DNA Contact		4	Deleterious	Missense	Non-Active
16b	7	THR-256-ILE	ACA > ATA	p.T256I	C.767C > T	L3				4	Deleterious	Missense	Partially Active
21	8	ARG-273-CYS	CGT > TGT	p.R273C	C.817C > T	LSH	Hotspot	Direct DNA Contact	CpG	5	Deleterious	Missense	Non-Active
22	8	GLY-279-GLU	GGG > GAG	p.G279E	C.836G > A	LSH				5	Deleterious	Missense	Non-Active
23	8	ARG-280-LYS	AGA > AAA	p.R280K	C.839G > A	LSH	Hotspot	Direct DNA Contact		5	Deleterious	Missense	Non-Active
24	8	GLU-286-LYS	GAA > AAA	p.E286K	C.856G > A	LSH				5	Deleterious	Missense	Non-Active
25a	5I	THR-140-ILE	ACC > ATC	p.T140I	C.419C > T	β				99	Deleterious	Missense	Partially Active
26a	5I	PRO-151-SER	CCC > CCT	p.P151S	C.451C > T	β		Direct DNA Contact		99	Deleterious	Missense	Non-Active
27	5I	ILE-162-MET	ATC > ATG	p.I162M	C.486C > G	β				99	Deleterious	Missense	Partially Active
28a	5II	VAL-172-ALA	GTG > GCG	p.V172A	C.515 T > C	L2				3	Deleterious	Missense	Active
29	5II	ARG-175-HIS	CGC > CAC	p.R175H	C.524G > A	L2	Hotspot	Direct DNA Contact	CpG	3	Deleterious	Missense	Non-Active
30	5II	GLY-187-ASP	GGT > GAT	p.G187D	C.560G > A	L2				3	Neutral	Missense	Active
26b	5II	GLY-187-ASP	GGT > GAT	p.G187D	C.560G > A	L2				3	Neutral	Missense	Active
31	7	MET-243-ILE	ATG > ATA	p.M243I	C.729G > A	L3		Direct DNA Contact		4	Deleterious	Missense	Non-Active
28b	8	VAL-272-MET	GTG > ATG	p.V272M	C.814G > A	LSH				5	Deleterious	Missense	Non-Active
32	8	ARG-290-CYS	CGC > TGC	p.R290C	C.868C > T	β			CpG	99	Deleterious	Missense	Active
25b	8	GLY-302-ARG	GGG > AGG	p.G302R	C.904G > A	C-Term				99	Neutral	Missense	Active

Back to article page

ISSN: 2051-5960

Contact us

Submission enquiries: JJM.Hoozemans@vumc.nl
General enquiries: info@biomedcentral.com

Acta Neuropathologica Communications

Contact us