C9orf72 is differentially expressed in the central nervous system and myeloid cells and consistently reduced in C9orf72, MAPT and GRN mutation carriers

Table 3 Summary of the RNA foci in CD14+ monocytes in C9orf72-HRE cases

	Patient 1 SF	Patient 2 SF	Patient 3 SF	Patient 1 ASF	Patient 2 ASF	Patient 3 ASF
Average	0.3	0.5	0.5	5.5	8.5	7.8
Median	0	0	0	3	4	4
Minimum	0	0	0	0	0	0
Maximum	10	4	6	25	38	35
%	17	29	25	90	79	85
n	72	75	106	70	132	131

The table summarizes sense and antisense foci counts from 3 patients with C9orf72-HRE
SF RNA sense foci, ASF RNA antisense foci
% = Percent of cells having at least one focus. No foci were detected in monocytes from an FTD patient without the repeat expansion
N = number of cells in which foci were counted automatically with a Cell Profiler speckle-counting algorithm

ISSN: 2051-5960