Pathological tau deposition in Motor Neurone Disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy

Table 3 Significance values for Kruskal-Wallis comparisons of degree of AT8, pThr¹⁷⁵ and pThr²¹⁷ tau immunostaining in CA1 region of hippocampus, entorhinal cortex, temporal cortex and frontal cortex for all 80 patients, collectively or when stratified according to clinical phenotype, or tau pathological profile

Group	CA1	Entorhinal cortex	Temporal cortex	Frontal cortex
All cases (n = 80)	0.726	0.544	0.834	0.877
MND (n = 41)	0.758	0.518	0.963	0.371
FTD + MND (n = 16)	0.675	0.577	0.231	0.993
FTD (n = 23)	0.935	0.753	0.717	0.544
Tau group 1 (n = 35)	0.621	0.607	0.759	0.539
Tau group 2 (n = 4)	1.000	0.368	0.113	0.005
Tau group 3 (n = 2)	0.535	0.852	0.275	0.882

bolded figures indicate significant difference in staining between the three anti-tau antibodies

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