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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions

Fig. 7

Insoluble tau is hyperphosphorylated at 7 days. a Representative western blots for analysis of tau expression for total tau by DAKO and the phospho-tau by AT180. b i) Quantification using the sum of all fractions shows no significant change in total or phospho-tau in the soluble fraction. (iii) AT180 significantly increases by 7 days in OA injected mice in the insoluble fraction compared to DMSO injected controls. The ratio of phosphorylated tau as noted by the AT180/total tau is significantly increased in the RIPA (iv) fractions but is unchanged in RAB fractions (ii). (n = 3, *p < 0.05)

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