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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer’s APP/PSEN1 mice by gene targeting of diabetes/Alzheimer’s-related Sorcs1

Fig. 1

Female but not male Sorcs1 -/- x APP/PSEN1 mice display impaired memory. Spontaneous alternation (SA) was assessed at 5 mo (a, b) and re-tested again at 9 mo (e, f), while novel object recognition (NOR) was assessed at 5 mo (c, d) in cohorts of male and female WT (n = 11–14/group), Sorcs1 -/- (n = 15–16/group), APP/PSEN1 (n = 6–11/group) and Sorcs1 -/- x APP/PSEN1 (n = 9/group). One-way ANOVA with Bonferroni posthoc analyses; *P < 0.05, **P < 0.01 and ***P < 0.001. Data expressed as mean ± s.e.m

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