PI3 kinase mutations and mutational load as poor prognostic markers in diffuse glioma patients

Table 7 multivariate Cox analysis of prognostic markers for overall survival in diffuse glioma patients

	HR	P value	95 % CI
Histology	1.00
Oligoastrocytoma vs. oligodendroglioma	1.53	0.22	0.78–3.02
Astrocytoma vs. oligodendroglioma	2.19	0.015	1.17–4.11
Grade	1.00
III vs. II	2.46	0.0040	1.33–4.54
IV vs. II^*	6.41	<0.0001	2.11–4.57
Age	1.00
> 50 vs. ≤50	3.10	<0.0001	2.11–4.57
Mutational load	1.00
> 40 vs. ≤ 40	0.69	0.066	0.47–1.03

A total of 542 samples were analyzed for this table. HR: Hazard Rate; CI: Confidence interval. Grade levels were 2, 3 and 4. Three histology levels were used (oligodendroglioma, oligoastrocytoma and astrocytoma), GBMs were categorized as astrocytomas

ISSN: 2051-5960