PI3 kinase mutations and mutational load as poor prognostic markers in diffuse glioma patients

Table 2 Frequency of genetic changes listed per histological subtype and grade

	Low grade	Molecular Oligodendroglioma		Molecular Astrocytoma		Molecular glioblastoma
	IDH1/IDH2	CIC/FUBP1	LOH 1p19q	ATRX	TP53	EGFR alterations	PTEN	alt 7/10	NF1	N
OD II	95	48	51	28	28	0	2	3	2	65
OD III	82	49	60	18	27	7	2	7	7	45
A II	83	0	0	67	73	0	0	0	0	30
A III	62	1	1	41	65	26	13	26	15	68
OA II	95	14	21	69	74	0	0	2	5	42
OA III	74	10	13	48	58	16	6	16	3	31
GBM	5	0	0	5	30	55	31	71	10	261
N	228	64	74	131	222	170	93	214	44	542

The numbers in the table are percentages of the number of samples mutated (i.e. population frequencies) except the columns listed as N where absolute numbers are given.

ISSN: 2051-5960