Fig. 8

Western blotting of eukaryotic initiation factors eIF1, eIF2-α, eIF3, eIF3 , and eIF5, and elongation factors eF1A and eF2 in the substantia nigra (a) and frontal cortex area 8 (b). Significantly increased expression of eIF3 and eEF2, more marked at stages 5–6, is observed in the substantia nigra in PD compared with MA individuals. In contrast, eIF3 expression is significantly reduced in frontal cortex area 8 at stages 3–4 and 5–6, whereas eIF1 is significantly increased at stage 5–6. Expression of elongation factors eF1A and eF2 is also significantly reduced in the frontal cortex in PD; β-actin is used as a control of protein loading. AU:arbitrary units. *p < 0.05; **p < 0.01