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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson’s disease

Fig. 7

a-c: Nucleophosmin (NPM1) immunohistochemistry in the substantia nigra pars compacta in PD at stages 1–2 (a), 3–4 (b), and 5–6 (c) showing NPM1 immunoreactivity in the nucleoli (arrows). The number and intensity of NPM1 immunoreactivity decreases at advanced stages of PD. d-f: Nucleoplasmin 3 (NPM3) immunohistochemistry in the substantia nigra pars compacta in PD at stages 1–2 (d), 3–4 (e), and 5–6 (f) showing preserved NPM3 immunoreactivity in the nucleolus (arrows). Paraffin section without haematoxylin counterstaining, bar = 50 μm

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