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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells

Fig. 1

The A673T substitution in APP decreased sAPPβ secretion, but not C99. Constructs used in this study. The APP695- or C99-coding fragment was inserted prior to IRES-GFP in pMXIG (a). APP A673T cells released one third of the levels of sAPPβ compared with those of wild-type APP. However, C99 levels in APP A673T cells were statistically indistinguishable from those of APP WT cells (b). Levels of sAPPβ and C99 were normalized for amount of APP (c). C99 level in APP A673T cells was almost identical to that in wild-type APP cells, as well as from internal standard GFP expression levels (d). Data represent means ± SD of three independent experiments. NS, not significant; * P < 0.05 (unpaired t-test)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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