Fig. 5
From: Muscarinic M1 receptors modulate endotoxemia-induced loss of synaptic plasticity
LPS treatment does not affect spike numbers or depolarization induced with high frequency stimulation. a Representative traces showing AP bursts induced by 4 successive high frequency stimulations (HFS, 100 Hz for 1 s) in the control rat (ctrl, scale bars: 50 mV, 500 ms. Histograms show the mean ± SEM values of the total number of spikes (b) and total AUC (c) from all 4 HFS trains used to induce LTP in Fig. 4. ** p < 0.01, *** p < 0.001 (ANOVA followed by Dunnett’s multiple comparisons test). Control: n = 8 cells; LPS: n = 10 cells; control + apamin: n = 6 cells; LPS + apamin: n = 8 cells; control + physo: n = 6 cells; LPS + physo: n = 6 cells; control + TBPB: n = 7 cells; LPS + TBPB: n = 7 cells