Fig. 3
From: Cortical tau load is associated with white matter hyperintensities
Partial Spearman’s (ρ') (HPτ-IR and Aβ-IR) and Pearson’s (r') (WM SI) correlation coefficients controlling for the effect of age at death. Scatter graphs show correlations between cortical percentage area covered by HPτ-IR (AT8 antibody for hyperphosphorylated tau burden), Aβ-IR (4G8; for amyloid-β depositions/plaques) and total white matter sclerotic index (WM SI; measure of small vessel disease severity) with age related white matter change score (ARWMC; measure for white matter hyperintensities) in the frontal (a-c), temporal (d-f), parietal (g-i) and occipital (j-l) regions, as well as total values representing the entire hemisphere (m-o). Analysis revealed that in all regions, and the entire hemisphere, significant correlations were observed between ARWMC scores and cortical HPτ-IR and Aβ-IR values, respectively. A significant relationship between ARWMC scores and WM SI were observed only in the occipital lobe. Of note, a correlation was observed between total SI and total ARWMC scores but this is likely due to the correlation in the occipital region. Only significant p values (and associated correlation coefficients (ρ’, r’)) are shown; for all correlation please see main text