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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons

Fig. 8

Impaired dendritic transport of recycling endosomes in APPOSK-expressing neurons. Rat primary neurons were triply transfected with APP, TfR-GFP, and BFP. a Transports of TfR in living neurons were recorded for 100 s, and those in 45-μm segments of the dendrite were analyzed. b Compared with mock-transfectants, bidirectional transport of TfR-positive vesicles in dendrites was reduced in APPOSK-, but not APPWT-, expressing cells

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Acta Neuropathologica Communications

ISSN: 2051-5960

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