Histological criteria for atypical pituitary adenomas – data from the German pituitary adenoma registry suggests modifications

Table 2 Statistical values of the main histomorphological parameters

Diagnostic Parameters for APAs/TPAs	Cut-off	Sensitivity	Specitifity	Youden-Index	Accuracy in %	AUC	95 % CI of AUC	OR	95 % CI of OR	P-value
Ki-67 pos. nuclei in %	≥4	0.95	0.97	0.92	96	0.98	[0.96; 1.0]	5.2	[3.43; 7.83]	<0.001
P53 pos. nuclei in %	≥2	0.85	0.93	0.78	90	0.94	[0.90; 0.97]	3.1	[2.31; 4.04]	<0.001
Mitotic Index in 10 HPF	≥2	0.90	0.74	0.64	79	0.89	[0.84; 0.93]	2.1	[1.70; 2.57]	<0.001
Invasiveness	Yes	0.88	0.53	0.41	64	-	-	8.2	[3.66; 18.42]	<0.001

The proposed threshold values for Ki-67, p53, number of mitotic figures in 10 HPF (high power fields) and the status of invasive tumor growth, to distinguish APA and TPA are shown with their respective statistical values
OR odds ratio, AUC area under curve, CI confidence interval

ISSN: 2051-5960