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Table 2 Statistical values of the main histomorphological parameters

From: Histological criteria for atypical pituitary adenomas – data from the German pituitary adenoma registry suggests modifications

Diagnostic Parameters for APAs/TPAs Cut-off Sensitivity Specitifity Youden-Index Accuracy in % AUC 95 % CI of AUC OR 95 % CI of OR P-value
Ki-67 pos. nuclei in % ≥4 0.95 0.97 0.92 96 0.98 [0.96; 1.0] 5.2 [3.43; 7.83] <0.001
P53 pos. nuclei in % ≥2 0.85 0.93 0.78 90 0.94 [0.90; 0.97] 3.1 [2.31; 4.04] <0.001
Mitotic Index in 10 HPF ≥2 0.90 0.74 0.64 79 0.89 [0.84; 0.93] 2.1 [1.70; 2.57] <0.001
Invasiveness Yes 0.88 0.53 0.41 64 - - 8.2 [3.66; 18.42] <0.001
  1. The proposed threshold values for Ki-67, p53, number of mitotic figures in 10 HPF (high power fields) and the status of invasive tumor growth, to distinguish APA and TPA are shown with their respective statistical values
  2. OR odds ratio, AUC area under curve, CI confidence interval
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