Fig. 2

Statistical analysis of the mitotic index, Ki-67 and p53 in the groups of TPA and APA. The Boxplot and Receiver operator curve (ROC) analysis based on the mitotic index (=number of mitosis counted in 10 high power fields (HPF); 400x magnification; a) and the values of tumor cell nuclei showing a distinct Ki-67 (b) and p53 (c) expression (%) in hot spot areas of the single tumor samples. The Y-axis is log scaled to figure out a clearer illustration of the lower values. Single outliers are presented as circles. The range and distribution of the analyzed parameters Ki67, p53 and number of mitotic figures in both subgroups (TPAs/APAs) is visualized using box plots. The boxes represent the 25th and the 75th percentiles, including the median value as a dark horizontal bar