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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Complete loss of the DNAJB6 G/F domain and novel missense mutations cause distal-onset DNAJB6 myopathy

Fig. 3

Immunolocalization of various proteins in patients 1 to 4s and III:3, showing that DNAJB6 staining is present on the rim of nuclei and in the cytoplasm of the fibers, where it co-localizes at the z discs with desmin, and on the surface and cytoplasmic inclusion of vacuolated fibers; desmin is normally expressed; myotilin is present in few inclusions in rare fibers; LC3 is present in the lumen and on the rim of vacuoles and in subsarcolemmal sarcoplasmic inclusions; p62 is present in sarcoplasmic inclusions and vacuoles with variable intracellular distribution and co-localizes with TDP43 and with BAG3

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Acta Neuropathologica Communications

ISSN: 2051-5960

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