Fig. 4
From: Impact of amyloid β aggregate maturation on antibody treatment in APP23 mice
Soluble, dispersible, membrane-associated, and plaque-associated Aβ in APP23 mice: Effects of β1 antibody treatment. Semiquantitative comparison of Aβ, AβN3pE, and pAβ in the soluble, dispersible, membrane-associated, and plaque-associated fraction of brain homogenates of PBS- and β1-treated 5- and 11-month-old APP23 mice received by quantification of western blots displayed in Additional file 8: Figure S5. No differences between PBS- and β1-treated animals except for plaque-associated Aβ in 5-month-old mice: β1-treated animals exhibited slightly more non-modified plaque-associated Aβ than non-treated mice. AβN3pE and pAβ were not detected in brain homogenates of 5-month-old APP23 mice but in the dispersible, membrane-associated, and plaque-associated fraction of 11-month-old mice without differences in relation to the treatment. Graphs represent mean values (white symbols 5-month-old mice; black symbols 11-month-old mice) and standard errors (whiskers). (* p < 0.05; detailed Statistical analysis in Additional file 3: Table S3)