Fig. 2

Co-expression of TDP-43^WT and TDP-43^Q331K in mice results in motor dysfunction and premature death. a TDP-43^WTxQ331K (orange triangle symbol) mice display a significant impairment in performance on the rotarod at 5 weeks of age, compared to NTg (green triangle symbol), TDP-43^WT (blue triangle symbol) and TDP-43^Q331K (red triangle symbol) age matched animals. Aging resulted in a significant impairment in motor function in all animals, regardless of genotype, but this impairment was significantly enhanced in TDP-43^Q331K mice compared to their NTg and TDP^WT littermates (mean ± SEM; * p < 0.05; ** p < 0.001 vs all other age matched genotypes; † p < 0.05). b Survival curve showing an average survival of 64 ± 6 days for TDP-43^WTxQ331K mice, while TDP-43^Q331K and TDP-43^WT survival does not significantly differ from NTg mice. c Abnormal hind limb splay in 8 week old TDP-43^WTxQ331K mouse. d Abnormal hind limb splay in a 24 month old TDP-43^Q331K mouse