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Table 1 Cohort demographics and numbers

From: Disease-related microglia heterogeneity in the hippocampus of Alzheimer’s disease, dementia with Lewy bodies, and hippocampal sclerosis of aging

case

age at death

Final MMSE

sex

ApoE alleles

PMI (h)

Braak stage

CERAD plaque stage

diffuse plaques

neuritic plaques

NFTs

diffuse Lewy bodies

NC = non-demented control: mean age =86; mean MMSE = 30; Median Braak stage = 2; Median CERAD = 0

1

81

30

M

3 / 3

2.17

2

0

0

0

0

0

2

91

30

M

n/a

n/a

2

0

0

0

1.4

0

3

86

30

M

3 / 3

2.17

3

0

0

0

4.6

0

4

93

30

F

3 / 3

2.25

2

0

0

0

0.25

0

5

84

30

M

2 / 3

3.25

0

0

n/a

n/a

n/a

0

6

85

30

M

3 / 3

2

3

1

2

0.5

8

0

7

84

30

F

3 / 3

2.42

0

0

0

0

0

0

8

92

30

F

2 / 3

3.25

3

2

5

0

0.75

0

9

81

30

M

3 / 4

2

2

2

2

10.5

1

0

HS = hippocampal sclerosis of aging: mean age =87; mean MMSE = 22.7; Median Braak stage = 2; Median CERAD = 0

10

74

20

M

3 / 4

8

3

2

0

0

1.4

0

11

95

16

F

3 / 4

3.25

3

0

0

0

1

0

12

87

28

F

3 / 3

1.82

3

0

0

0

4

0

13

84

10

F

n/a

2.57

2

0

0

0

0

0

14

91

29

F

2 / 3

2.87

2

1

0

0

6.8

0

15

91

30

M

3 / 3

2.83

2

0

n/a

n/a

n/a

0

16

88

26

M

3 / 4

2.33

0

0

0

0

0

0

AD = Alzheimer’s disease: mean age =77; mean MMSE = 11; Median Braak stage = 6; Median CERAD = 3

17

75

18

F

3 / 4

2.5

6

3

9

0.33

25

0

18

84

13

M

4 / 4

5.17

6

3

4

1.33

26.75

0

19

65

3

F

3 / 4

4.1

6

3

2.67

1.67

41

0

20

85

4

F

3 / 3

11.2

6

3

6.67

1.33

78.8

0

21

79

6

M

n/a

2.08

6

3

4.33

2.33

25.6

0

22

67

11

M

2 / 3

1.75

6

3

0.33

0

2.4

+

23

82

25

M

n/a

2.75

6

2

1.67

2.67

19.8

+

AD + HS: mean age =91; mean MMSE = 7.8; Median Braak stage = 6; Median CERAD = 3

24

96

6

F

3 / 3

6.75

6

3

n/a

n/a

n/a

0

25

91

13

F

3 / 3

3

5

3

6.67

1.33

34

0

26

91

12

F

4 / 4

2.33

6

3

0

0

10.25

+

27

87

0

F

3 / 3

2.67

6

3

0

0

54.6

0

DLB = Dementia with Lewy bodies: mean age =80; mean MMSE = 17.25; Median Braak stage = 2; Median CERAD = 1

28

65

9

M

4 / 4

9.5

2

3

2

7.67

2

+

29

61

18

M

3 / 3

2

2

0

0

0

9.6

+

30

85

2

F

2 / 3

2

2

3

4

6.67

3.6

+

31

85

27

M

3 / 3

11.2

2

1

0

0

0.8

+

32

89

27

M

3 / 3

2.42

2

0

0

0

8.5

+

33

92

27

F

3 / 4

2.42

2

1

0.67

0

2

+

34

68

11

M

3 / 4

3.75

2

2

0

0

0.4

+

35

81

15

M

3 / 3

2.42

2

2

1.5

2.5

0.25

+

36

78

9

M

3 / 3

2.5

1

0

0

0

2

+

37

81

26

M

3 / 3

5.77

1

1

0

0

0

+

38

97

21

M

2 / 3

3.5

1

0

0

0

1.8

+

39

78

15

M

3 / 4

n/a

1

1

3.5

0.5

0

+

  1. Counts in the hippocampus of neurofibrillary tangles (NFTs), and amyloid plaques, without neurites (diffuse plaques), and with degenerating neurites (neuritic plaques) (see [42]). Abbreviations: Apo E apolipoprotein E; PMI = post-mortem interval; MMSE = mini-mental state examination; +, feature present; n/a = not available
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