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Table 1 Cohort demographics and numbers

From: Disease-related microglia heterogeneity in the hippocampus of Alzheimer’s disease, dementia with Lewy bodies, and hippocampal sclerosis of aging

case age at death Final MMSE sex ApoE alleles PMI (h) Braak stage CERAD plaque stage diffuse plaques neuritic plaques NFTs diffuse Lewy bodies
NC = non-demented control: mean age =86; mean MMSE = 30; Median Braak stage = 2; Median CERAD = 0
1 81 30 M 3 / 3 2.17 2 0 0 0 0 0
2 91 30 M n/a n/a 2 0 0 0 1.4 0
3 86 30 M 3 / 3 2.17 3 0 0 0 4.6 0
4 93 30 F 3 / 3 2.25 2 0 0 0 0.25 0
5 84 30 M 2 / 3 3.25 0 0 n/a n/a n/a 0
6 85 30 M 3 / 3 2 3 1 2 0.5 8 0
7 84 30 F 3 / 3 2.42 0 0 0 0 0 0
8 92 30 F 2 / 3 3.25 3 2 5 0 0.75 0
9 81 30 M 3 / 4 2 2 2 2 10.5 1 0
HS = hippocampal sclerosis of aging: mean age =87; mean MMSE = 22.7; Median Braak stage = 2; Median CERAD = 0
10 74 20 M 3 / 4 8 3 2 0 0 1.4 0
11 95 16 F 3 / 4 3.25 3 0 0 0 1 0
12 87 28 F 3 / 3 1.82 3 0 0 0 4 0
13 84 10 F n/a 2.57 2 0 0 0 0 0
14 91 29 F 2 / 3 2.87 2 1 0 0 6.8 0
15 91 30 M 3 / 3 2.83 2 0 n/a n/a n/a 0
16 88 26 M 3 / 4 2.33 0 0 0 0 0 0
AD = Alzheimer’s disease: mean age =77; mean MMSE = 11; Median Braak stage = 6; Median CERAD = 3
17 75 18 F 3 / 4 2.5 6 3 9 0.33 25 0
18 84 13 M 4 / 4 5.17 6 3 4 1.33 26.75 0
19 65 3 F 3 / 4 4.1 6 3 2.67 1.67 41 0
20 85 4 F 3 / 3 11.2 6 3 6.67 1.33 78.8 0
21 79 6 M n/a 2.08 6 3 4.33 2.33 25.6 0
22 67 11 M 2 / 3 1.75 6 3 0.33 0 2.4 +
23 82 25 M n/a 2.75 6 2 1.67 2.67 19.8 +
AD + HS: mean age =91; mean MMSE = 7.8; Median Braak stage = 6; Median CERAD = 3
24 96 6 F 3 / 3 6.75 6 3 n/a n/a n/a 0
25 91 13 F 3 / 3 3 5 3 6.67 1.33 34 0
26 91 12 F 4 / 4 2.33 6 3 0 0 10.25 +
27 87 0 F 3 / 3 2.67 6 3 0 0 54.6 0
DLB = Dementia with Lewy bodies: mean age =80; mean MMSE = 17.25; Median Braak stage = 2; Median CERAD = 1
28 65 9 M 4 / 4 9.5 2 3 2 7.67 2 +
29 61 18 M 3 / 3 2 2 0 0 0 9.6 +
30 85 2 F 2 / 3 2 2 3 4 6.67 3.6 +
31 85 27 M 3 / 3 11.2 2 1 0 0 0.8 +
32 89 27 M 3 / 3 2.42 2 0 0 0 8.5 +
33 92 27 F 3 / 4 2.42 2 1 0.67 0 2 +
34 68 11 M 3 / 4 3.75 2 2 0 0 0.4 +
35 81 15 M 3 / 3 2.42 2 2 1.5 2.5 0.25 +
36 78 9 M 3 / 3 2.5 1 0 0 0 2 +
37 81 26 M 3 / 3 5.77 1 1 0 0 0 +
38 97 21 M 2 / 3 3.5 1 0 0 0 1.8 +
39 78 15 M 3 / 4 n/a 1 1 3.5 0.5 0 +
  1. Counts in the hippocampus of neurofibrillary tangles (NFTs), and amyloid plaques, without neurites (diffuse plaques), and with degenerating neurites (neuritic plaques) (see [42]). Abbreviations: Apo E apolipoprotein E; PMI = post-mortem interval; MMSE = mini-mental state examination; +, feature present; n/a = not available
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Acta Neuropathologica Communications

ISSN: 2051-5960

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