Figure 9

Preventive MB treatment does not rescue cognitive decline of TauRD^ΔK mice. MWM test shows cognitive abilities of TauRD^ΔK mice after preventive MB application for 14.5mo. (a) MB-treated as well as untreated TauRD^ΔK animals show impaired learning abilities similar to untreated TauRD^ΔK littermates, as indicated by increased path lengths to reach the hidden platform in MWM acquisition in comparison to WT. Data shows mean path length ± SEM. (b) Preventive MB treatment for 14.5mo does not result in a higher preference of the target quadrant as compared to untreated TauRD^ΔK mice and controls. Bars represent mean values ± SEM. Statistics: two-tailed one sample t-test against chance level of 25%; *: p < 0.05; **: p < 0.01; n = number of animals; T: target quadrant; R: right quadrant; O: opposite quadrant; L: left quadrant; LTPT: long-term probe trial.