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Table 1 Staining and immunostaining peformed, per brain region

From: A novel mutation P112H in the TARDBP gene associated with frontotemporal lobar degeneration without motor neuron disease and abundant neuritic amyloid plaques

Region

H&E

Gallyas

A-beta

p-tau

p62

TDP-43

a-syn

Side

Frontal pole, medial

x

    

x

 

R

Anterior orbital gyrus

x

    

x

 

R

Anterior middle cingulate cortex

x

 

x

x

 

x

x

R

Middle front gyrus

x

x

x

x

  

x

R*

Inferior frontal gyrus

x

      

R

Ventral striatum

x

  

x

 

x

 

R

Inferior temporal gyrus

x

x

x

x

 

x

 

R*

Amygdala

x

    

x

x

R

Insula/ Putamen

x

 

x

x

   

R*

Globus Pallidus

x

      

R

Superior frontal sulcus

x

      

R

Hippocampus/ entorhinal cortex

x

 

x

x

x

x

 

R*

Superior temporal gyrus

x

 

x

x

   

R

Sensorimotor cortex

x

  

x

 

x

 

R

Thalamus

x

  

x

   

R

Angular gyrus

x

x

x

x

   

R*

Posterior cingulate cortex

x

  

x

   

R

Calcarine cortex

x

 

x

x

   

R

Cerebellum including the dentate nucleus

x

 

x

 

x

  

R

Rostral midbrain

x

 

x

x

 

x

x

B

Caudal midbrain

x

  

x

 

x

 

B

Rostral pons

x

  

x

 

x

x

B

Caudal pons

x

  

x

 

x

 

B

Medulla oblongata

x

  

x

 

x

x

B

Spinal cord ( 4 levels )

x

    

x

 

B

  1. A-beta: immunohistochemistry against beta-amyloid; a-syn: immunohistochemistry against alpha-synuclein; p-tau: immunohistochemistry against phospho-tau; B: bilateral; Gallyas: Gallyas silver staining; H & E: Hematoxylin and eosin staining; p62: immunohistochemistry against protein p62; R: right hemisphere; R*: both hemispheres on index patient; TDP-43: immunohistochemistry against protein TDP-43.