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Figure 7 | Acta Neuropathologica Communications

Figure 7

From: Loss of angiotensin II receptor expression in dopamine neurons in Parkinson’s disease correlates with pathological progression and is accompanied by increases in Nox4- and 8-OH guanosine-related nucleic acid oxidation and caspase-3 activation

Figure 7

Intranuclear expression of Nox4 is associated with intranuclear oxidative damage to nucleic acids. Nox4 expression favors nuclear localization in dopamine (pigmented) neurons in prePD and PD patients as compared to AMC individuals (A-C). Quantification of the percent of dopamine neuron nuclei that are Nox4+ (D). Oxidative stress-induced damage to the nucleic acids is demonstrated by a shift of immunohistofluorescently-detected StressMarq signature of oxidized guanosine (8-OH guanosine) into the nuclei of dopamine neurons (E-G) – quantified in panel H. Scale bar is 20 μm. Arrows point to neurons with intranuclear expression of Nox4 or presence of StressMarq-identified 8-OH guanosine. Asterisks in (D and H) identify significant differences from AMC.

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Acta Neuropathologica Communications

ISSN: 2051-5960

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