Table 1 Demographic characteristics of cohorts
From: Phosphorylated α-synuclein in Parkinson’s disease: correlation depends on disease severity
Baseline (N = 95) | Final (N = 95) | UW-collaborative (N = 209) | LRRK2 (N = 30) | |
|---|---|---|---|---|
Age, y (mean ± SD) | 61.08 ± 8.91 | 63.08 ± 8.68 | 65.94 ± 10.54 | 53.13 ± 13.88 |
Sex F/M (% Male) | 35/60 (63%) | 35/60 (63%) | 52/157 (75%) | 15/15 (50%) |
Duration of disease, y | ||||
Mean ± SD | 1.9 ± 1.41 | 4.02 ± 1.55 | 7.9 ± 6.48 | -- |
Range | 0 – 6 | 1 – 9 | 0 – 42 | |
MMSE | ||||
Mean ± SD | 28.85 ± 1.57 | 28.81 ± 1.48 | 28.47 ± 3.07 | -- |
Range | 23 – 30 | 22 – 30 | 11 – 30 | |
H&Y† | ||||
Median | 2.0 | 2.0 | 2.0 | -- |
Range | 1.0 – 2.5 | 1.0 – 4.0 | 0.0 – 5.0 | |
UPDRS‡ Total | ||||
Mean ± SD | 24.87 ± 12.50 | 40.73 ± 16.63 | -- | -- |
Range | 0 – 61 | 9 – 88 | ||
UPDRS Motor | ||||
Mean ± SD | 16.90 ± 9.52 | 27.36 ± 12.13 | 23.72 ± 11.87 | 5.20 ± 4.73 |
Range | 0 – 50 | 5 – 62 | 0 – 71 | 0 – 20 |
Ps129 (pg/ml) | ||||
Mean ± SD | 114.66 ± 17.14 | 117.89 ± 17.92 | 74.01 ± 26.67 | 63.79 ± 22.73 |
Range | 57.11 – 151.63 | 68.66 – 170.78 | 0.00 – 203.17 | 35.2 – 145.1 |
Total α-syn (pg/ml) | ||||
Mean ± SD | 630.83 ± 703.08 | 639.48 ± 677.95 | 553.61 ± 409.22 | 744.78 ± 1169.94 |
Range | 186.3 – 6343.5 | 173.6 – 4523.0 | 140.0 – 2990.0 | 170.98 – 5735.08 |
Ratio | ||||
Mean ± SD | 0.2530 ± 0.1232 | 0.2688 ± 0.1433 | 0.177 ± 0.098 | 0.172 ± 0.132 |
Range | 0.01 – 0.77 | 0.02 – 0.86 | 0.00 – 0.53 | 0.01 – 0.56 |