Figure 4
From: WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma
Survival of normal neuronal stem cells (Hf5205) after the combination treatment with 2 mM lithium and radiation. A) Survival curves for normal neuronal stem cells given increasing radiation doses following 24 hours of exposure to lithium (red) and untreated control (blue) (p = 0.054). B) Immunofluorescent imaging of normal neuronal stem cells; absence of the nuclear translocation of β-catenin (green) is observed in both control (top panel) and lithium treated (bottom panel) cells, nucleus (DAPI-red). C) γH2AX foci in non-irradiated cells and 24 hours post irradiation: γH2AX foci (green), nucleus (DAPI-blue).