Mitochondrial abnormalities and low grade inflammation are present in the skeletal muscle of a minority of patients with amyotrophic lateral sclerosis; an observational myopathology study

Table 1 Summary of muscle pathology in ALS/MND patients

Age/sex	NC	Infl	Nec	COX -ve	HLA	C5b-9	P62	TDP	CK
54 M	+	+	-	-	-	+ F	+	-	350
54 M	+	+	-	-	-	+ C	+	-	350
54 M	+	-	+	-	+	+ F	+	-	107
75 F	+	-	+	2%	+	+ F	+	-	114
56 M	+	-	-	-	-	-	-	-	443
61 F	+	-	-	-	-	-	-	-	285
57 M	+	-	-	-	-	+ F	+	-	337
27 M	+	-	-	-	-	+ F	+	-	313
45 M	+	-	-	-	-	-	-	-	151
57 F	-	+	-	-	-	+ F	-	-	47
57 F	-	+	-	-	-	+ C	-	-	47
36 M	+	-	-	-	-	-	-	-	143
29 M	+	-	-	-	-	-	+	-	170
66 M	+	-	-	3%	-	-	-	-	82
69 M	+	-	-	-	-	+ F	-	-	267
66 M	+	-	-	-	+	+ F	-	-	119
61 M	+	-	-	-	-	+ F	-	-	807
60 M	+	-	-	-	-	+ F	-	-	295
59 F	+	+	+	-	-	-	-	-	145
34 M	+	+	+	-	+	+ F	-	-	1386
47 F	+	-	-	-	-	+ F	-	-	108
41 M	+	-	-	-	-	+ F	-	-	238
67 M	+	-	-	1%	-	+ F	-	-	148
40 M	+	-	-	-	+	+ C	+	-	166
60 F	+	-	-	3%	-	+ F	-	-	252
61 F	+	-	-	2%	-	+ F	-	-	99
55 M	+	-	-	-	-	+ F	-	-	391
50 M	+	+	-	-	-	+ F	-	-	963
67 F	+	-	-	-	-	+ F	+	-	52
61 F	+	-	-	-	-	+ F	-	-	318
65 M	+	-	-	-	-	+ F	-	-	150
48 F	+/−	-	+	-	-	-	-	-	130
67 M	+	-	-	-	-	-	-	-	425

NC: neurogenic changes; Infl: inflammation; Nec: Necrosis. C: capillaires. F: fibres.