Figure 7
Comparison of PrP Sc stabilities to GdnHCl denaturation in various brain regions from a VPSPr and GSS cases. The [GdnHCl]½ values obtained from various brain regions from a VPSPr case, two GSS cases (type 1 and ~8 kDa PrPres case) and a sCJD VV2 case are plotted to scale (units of molar concentration of GdnHCl) on a vertical axis from [GdnHCl]½ =1.5 M at the bottom to [GdnHCl]½ =3.5 M. The [GdnHCl]½ values for VPSPr are shown in red on the left, whereas the GSS and sCJD VV2 values are on the right in green and blue, respectively. [GdnHCl]½ values (along with 95% confidence intervals for the curve fit) are also listed in Table 3.