Figure 3

FPI-induced alterations in peripheral lymphocytes require CD74. (A) The number of viable cells in the spleens of CD74^Def mice is unchanged at 24 hours following sham surgery or FPI. (B) Similarly, the number of B Cells (B220⁺) and T cells (CD3⁺) in the spleens of CD74^Def mice are not significantly different at 24 hours after sham surgery or FPI. (C) Analysis of specific populations of T cells also revelaed no significant differences at 24 hours after sham surgery or FPI. For these experiments we used 5 sham surgery mice and 6 FPI treated mice. The symbol * indicates P < 0.05.