FPI-induced alterations in peripheral lymphocytes require CD74. (A) The number of viable cells in the spleens of CD74Def mice is unchanged at 24 hours following sham surgery or FPI. (B) Similarly, the number of B Cells (B220+) and T cells (CD3+) in the spleens of CD74Def mice are not significantly different at 24 hours after sham surgery or FPI. (C) Analysis of specific populations of T cells also revelaed no significant differences at 24 hours after sham surgery or FPI. For these experiments we used 5 sham surgery mice and 6 FPI treated mice. The symbol * indicates P < 0.05.