Skip to main content
Figure 10 | Acta Neuropathologica Communications

Figure 10

From: Dystonia type 6 gene product Thap1: identification of a 50 kDa DNA-binding species in neuronal nuclear fractions

Figure 10

Rrm1 mRNA level is altered by up- or down-regulation of Thap1 but mRNA and protein levels of torsinA are unchanged. (a) Rrm1 expression analysis by RT-qPCR in primary striatal neuronal cultures transduced with Ad-mThap1 virus for Thap1 overexpression, or Ad-GFP control. (*p < 0.05; Untreated level arbitrarily set at 100%; N = 3). (b) Rrm1 qPCR analysis in whole body of E9 Thap1-null embryos (diamonds), heterozygous (squares) and wildtype littermates (circles). (N = 2) (c) TorsinA protein levels in primary striatal neuronal cultures transduced with LV-mThap1 to overexpress Thap1 protein or treated with AAV-shRNA specific to mThap1.

Back to article page

Acta Neuropathologica Communications

ISSN: 2051-5960

Contact us