Figure 6

CCL2 mRNA in astrocytes and CCL2 induced microglial proliferation . Primary WM rat astrocytes produce significantly more CCL2 mRNA upon treatment with bz-ATP than GM astrocytes (A). Primary rat microglia significantly increased their proliferation rate upon treatment with CCL2. This effect was abolished when the cells were co-incubated with a CCR2 antagonist (B). Immunofluorescent double labelling study showed colocalization between BM28 and CCR2 in post mortem human hippocampal GML (C). * p < 0,05.