Quantification of CD68 immunopositive amoeboid microglia in the hippocampus (HC) of control subjects, iLBD cases and PD patients. (a-c) Numbers of CD68 positive amoeboid microglia were significantly lower in CA1 compared to all other pyramidal layers in (a) the control subjects, (b) iLBD cases and (c) PD patients (*p ≤ 0.02 vs CA2, CA3, CA4). A significant increase was observed in (a) CA3 compared to CA4 of control subjects (#p < 0.05 vs CA4), and in (b, c) CA2 and CA3 compared to CA4 in (b) iLBD cases and (c) PD patients (#p < 0.05, #p ≤ 0.01, respectively vs CA2, CA3). (d) Comparison of all groups together resulted in a significant increase in the numbers of CD68 positive amoeboid microglia in the PD patients relative to control and iLBD cases (data shown for CA2, *p < 0.01 vs iLBD, Ctr). Data represent mean ± SEM.