Figure 5From: Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson’s disease patients Quantification of CD68 immunopositive amoeboid microglia in the hippocampus (HC) of control subjects, iLBD cases and PD patients. (a-c) Numbers of CD68 positive amoeboid microglia were significantly lower in CA1 compared to all other pyramidal layers in (a) the control subjects, (b) iLBD cases and (c) PD patients (*p ≤ 0.02 vs CA2, CA3, CA4). A significant increase was observed in (a) CA3 compared to CA4 of control subjects (#p < 0.05 vs CA4), and in (b, c) CA2 and CA3 compared to CA4 in (b) iLBD cases and (c) PD patients (#p < 0.05, #p ≤ 0.01, respectively vs CA2, CA3). (d) Comparison of all groups together resulted in a significant increase in the numbers of CD68 positive amoeboid microglia in the PD patients relative to control and iLBD cases (data shown for CA2, *p < 0.01 vs iLBD, Ctr). Data represent mean ± SEM.Back to article page