Quantification of TLR2 immunoreactivity (IR) in the hippocampus (HC) of control subjects, iLBD cases and PD patients. (a) No significant differences in TLR2 IR were present between the different hippocampal regions within control subjects, (b) a significant increase in TLR2 IR was found in CA2, CA3 and CA4 compared to CA1 within iLBD cases (*p < 0.05 vs CA2, CA3, CA4). (c) In PD patients TLR2 IR was overall found at lower levels that were significantly increased in CA2 relative to the CA1, CA3 and CA4 (*p < 0.02 vs CA1, CA3, CA4) and also in CA3 compared to CA4 (#p < 0.02 vs CA4). (d) When TLR2 IR in all four hippocampal subregions was taken together, a significant increase was found in the iLBD cases compared to control subjects and PD patients (data shown for CA2, *p < 0.02). Data represent mean ± SEM.