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Figure 1 | Acta Neuropathologica Communications

Figure 1

From: Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson’s disease patients

Figure 1

α-Synuclein pathology and CD68 immunopositive microglia in the substantia nigra (SN) of control subjects, iLBD cases and PD patients. Brown staining depicts the melanin-containing, dopaminergic neurons that degenerate during PD. (a) No intraneuronal α-synuclein immunoreactivity (IR)(purple) was observed in the SN of control subjects, (b) some intraneuronal α-synuclein IR was found in the SN of iLBD cases (arrow), and (c) widespread intraneuronal and neuritic α-synuclein IR is observed in the SN of PD patients (LBs: arrows, LNs arrowhead); (d) a control subject showing some CD68 positive ramified microglial cells (purple, arrow), (e) an iLBD case showing prominent CD68 positive ramified (arrow) and amoeboid (concave arrowhead) microglial phenotypes, and (f) a PD patient, showing few CD68 positive ramified (arrow), but many more amoeboid microglial phenotypes (concave arrowhead); bar (a-f) = 100 μm.

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Acta Neuropathologica Communications

ISSN: 2051-5960

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