Figure 1
From: A neuronal function of the tumor suppressor protein merlin
Potential role for merlin isoform 2 in NF2-related neuropathy. Merlin isoform 2 in axons assembles a multi-protein complex with RhoGDI [[68]] and RhoGAP that leads to the local activation of the small GTPase RhoA by GTP loading [[45]]. This results in subsequent neurofilament phosphorylation through Rho-associated kinase (ROCK). The specific loss of merlin isoform 2 can therefore provoke irregular neurofilament phosphorylation and impaired axon structure maintenance.